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In our laboratory we have created fruit fly models of human neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and a number of less common disorders.  By expressing normal and mutant human alpha-synuclein in flies, we have recreated key features of the human disorder. We are now using the genetic tools available in Drosophila to identify proteins and cellular pathways controlling the pathogenesis of Parkinson disease.  We have taken a similar approach to studying Alzheimer’s disease, focusing on expression of human tau and Abeta in flies.

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